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Table 1 Summary of histopathological changes in lungs of SH rats exposed to particulate matter or saline.

From: Effects of particulate matter on the pulmonary and vascular system: time course in spontaneously hypertensive rats

Post-exposure time

24 hr

   

48 hr

   

Group

 

1

4

5

6

1

4

5

6

Number examined

9

9

9

9

10

10

10

10

Alveolar Mφ

minimal

2

6

3

5

4

6

3

-

 

slight

-

2

5

1

1

4

2

6

 

moderate

-

1

1

1

-

-

4

2

 

marked

-

-

-

-

-

-

-

2

 

overall

2

13

16

10

6

14

19

26

Inflammatory foci thick septa + alveolar Mφ

minimal

6

4

3

-

6

2

-

-

 

slight

3

5

3

3

2

4

-

-

 

moderate

-

-

3

3

2

4

7

3

 

marked

-

-

-

3

-

-

3

7

 

overall

12

14

18

27

16

22

33

37

BrdU score

number examined

6

6

6

6

6

6

6

6

 

minimal

2

-

-

-

6

1

-

-

 

slight

1

1

-

-

-

3

-

-

 

moderate

-

3

3

-

-

2

3

2

 

marked

-

2

2

3

-

-

3

2

 

strong

-

-

1

3

-

-

-

2

 

overall

4

19

22

27

6

13

21

24

  1. The lungs of SH rats exposed to saline (group1), 3 or 10 mg/kg of body weight RTD (respectively group 4 and 5) or 10 mg/kg of body weight EHC-93 (group 6) were examined at 24 or 48 hours post-exposure. In the overall score, a weight factor of 1 to 5 is included for the score minimal to strong. Abbreviations: Mφ – macrophages.