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Table 1 Morphological evaluation of the rat lungs after 2 hours perfusion and inhalation exposure to Ir-UFP, using lung sections and HE- or toluidine blue staining The regions investigated included the bronchial segment, the blood vessels and the alveolar region

From: The influence of hydrogen peroxide and histamine on lung permeability and translocation of iridium nanoparticles in the isolated perfused rat lung

Treatment Bronchial region Blood vessels Alveolar region
Control Sub epithelial round cell filtration; interstitial dilation Interstitial dilation Small alveolar dilation in periphery
Hydrogen peroxide Desquamation of epithelial layer, partially destruction of sub epithelial structure Moderate to severe dilation  
Histamine Perfusate Sub epithelial round cell filtration; interstitial dilation Moderate to severe interstitial dilation Alveolar dilation in periphery
Histamine (Bolus) Sub epithelial round cell filtration; interstitial dilation Moderate to severe interstitial dilation Focal alveolar dilation, oedematous fluid in alveolar lumen