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Table 2 Summary of effects of 100 μ g particles/ml/million cells on phagosome transport (relaxation) together with effect of co-incubation with different Ca-modulating drugs (100 μ M Verapamil, 20 μ M BAPTA-AM or 25 μ M W-7) as well as medium with serum (wFCS), with bovine serum albumin (BSA), or with 200 μ M Nacystelin (NAL); inhib. – inhibition, n.e. – no effect, accel. – acceleration; N = 5; **: p < 0.01, *: p < 0.05.

From: Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium

Drug

P90

EC90

DEP

UD

w/oFCS

inhib.**

inhib.**

accel.*

n.e.

Verap

inhib.*

n.e.

n.e.

n.e.

BAPTA

inhib.**

inhib.**

n.e.

n.e.

W-7

inhib.**

inhib.**

n.e.

n.e.

wFCS

n.e.

n.e.

n.e.

n.e.

BSA

n.e.

n.e.

n.e.

n.e.

NAL

inhib.**

inhib.**

n.e.

n.e.