Table 3 Summary of effects of 100 μ g particles/ml/million cells on cytoskeletal stiffness together with effect of co-incubation with different Ca-modulating drugs (100 μ M Verapamil, 20 μ M BAPTA-AM or 25 μ M W-7) as well as medium with serum (wFCS), with bovine serum albumin (BSA), or with 200 μ M Nacystelin (NAL); stiff. – stiffening, n.e. – no effect; N = 5; **: p < 0.01, *: p < 0.05.
From: Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium
Drug | P90 | EC90 | DEP | UD |
|---|---|---|---|---|
w/oFCS | stiff.* | stiff.** | n.e. | n.e. |
Verap | stiff.* | n.e. | n.e. | n.e. |
BAPTA | stiff.** | stiff.** | n.e. | n.e. |
W-7 | n.e. | stiff.** | n.e. | n.e. |
wFCS | n.e. | n.e. | n.e. | n.e. |
BSA | n.e. | n.e. | n.e. | n.e. |
NAL | stiff.** | stiff.** | n.e. | n.e. |