TY - JOUR AU - Oberdörster, Günter AU - Maynard, Andrew AU - Donaldson, Ken AU - Castranova, Vincent AU - Fitzpatrick, Julie AU - Ausman, Kevin AU - Carter, Janet AU - Karn, Barbara AU - Kreyling, Wolfgang AU - Lai, David AU - Olin, Stephen AU - Monteiro-Riviere, Nancy AU - Warheit, David AU - Yang, Hong AU - A report from the ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group PY - 2005 DA - 2005/10/06 TI - Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy JO - Particle and Fibre Toxicology SP - 8 VL - 2 IS - 1 AB - The rapid proliferation of many different engineered nanomaterials (defined as materials designed and produced to have structural features with at least one dimension of 100 nanometers or less) presents a dilemma to regulators regarding hazard identification. The International Life Sciences Institute Research Foundation/Risk Science Institute convened an expert working group to develop a screening strategy for the hazard identification of engineered nanomaterials. The working group report presents the elements of a screening strategy rather than a detailed testing protocol. Based on an evaluation of the limited data currently available, the report presents a broad data gathering strategy applicable to this early stage in the development of a risk assessment process for nanomaterials. Oral, dermal, inhalation, and injection routes of exposure are included recognizing that, depending on use patterns, exposure to nanomaterials may occur by any of these routes. The three key elements of the toxicity screening strategy are: Physicochemical Characteristics, In Vitro Assays (cellular and non-cellular), and In Vivo Assays. SN - 1743-8977 UR - https://doi.org/10.1186/1743-8977-2-8 DO - 10.1186/1743-8977-2-8 ID - Oberdörster2005 ER -