From: A method for exposing rodents to resuspended particles using whole-body plethysmography
BENEFITS | LIMITATIONS |
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• whole-body inhalation • real-time acquisition of respiratory data during exposure • capability to generate mixtures, as well as particles • simultaneous collection of pulmonary and cardiovascular data • can be modified for mice or rats | • low humidity • not able to obtain air flow data for individual WBP chambers during exposure • differences in particle distribution across WBP chambers • not able to expose large groups of animals simultaneously • equipment and space requirements • particles used must be from a bulk sample |