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Table 6 Benefits and limitations of the WBP exposure system

From: A method for exposing rodents to resuspended particles using whole-body plethysmography

• whole-body inhalation
• real-time acquisition of respiratory data during exposure
• capability to generate mixtures, as well as particles
• simultaneous collection of pulmonary and cardiovascular data
• can be modified for mice or rats
• low humidity
• not able to obtain air flow data for individual WBP chambers during exposure
• differences in particle distribution across WBP chambers
• not able to expose large groups of animals simultaneously
• equipment and space requirements
• particles used must be from a bulk sample