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Table 6 Benefits and limitations of the WBP exposure system

From: A method for exposing rodents to resuspended particles using whole-body plethysmography

BENEFITS

LIMITATIONS

• whole-body inhalation

• real-time acquisition of respiratory data during exposure

• capability to generate mixtures, as well as particles

• simultaneous collection of pulmonary and cardiovascular data

• can be modified for mice or rats

• low humidity

• not able to obtain air flow data for individual WBP chambers during exposure

• differences in particle distribution across WBP chambers

• not able to expose large groups of animals simultaneously

• equipment and space requirements

• particles used must be from a bulk sample