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Figure 6 | Particle and Fibre Toxicology

Figure 6

From: Single-Walled Carbon Nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages In Situ

Figure 6

Levels of growth factor and procollagen mRNAs in the lungs of rats exposed to SWCNT, CB, or V2O5. Whole lung RNA was extracted as described in Methods and mRNA expression measured by quantitative real-time RT-PCR. V2O5 was used as a positive control for inducing mRNA levels of profibrogenic mediators. (A) 1 day post-exposure. (B) 21 days post-exposure. Control animals were treated with vehicle alone (PBS with 0.1% Pluronic F-68). Data are presented as mean values ± SEM from three to five animals per group and expressed as the fold-change in mRNA relative to an 18S rRNA housekeeping gene. *P < 0.05 significantly increased or †P < 0.05 significantly decreased compared to control.

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