Figure 8

Light micrograph of lung tissue from a rat exposed to quartz particles (5 mg/kg) at 3 months post-instillation exposure. Note the tissue accumulation of foamy multinucleated alveolar macrophages (arrows) within alveolar spaces. The macrophages have migrated to the sites of quartz particle deposition at the terminal bronchiolar alveolar junctions. The accumulation of lipid-filled macrophages and lack of clearance is a common feature of the progressive nature of silica induced lung disease. Magnification = ×100.