Cytokine expression in mice exposed to diesel exhaust particles by inhalation. Role of tumor necrosis factor

Table 1 Expression of cytokines in lung tissue from BALBcJ mice exposed to SRM1650

Dose	Air			20 mg/m³ DEP			80 mg/m³ DEP
Time	1 h	3 h	1 day	1 h	3 h	1 day	1 h	1 day
Tnf	64 ± 23	41 ± 7.5	57 ± 43	49 ± 23	57 ± 7.7	100 ± 39	119 ± 70	178 ± 66**
Il-6	0.4 ± 0.3	0.2 ± 0.1	0.2 ± 0.1	1.0 ± 0.6**	0.2 ± 0.2	0.2 ± 0.01	3.5 ± 1.5**	0.9 ± 0.2**
Mcp-1	7.5 ± 4.7	21 ± 21	14 ± 20	8.5 ± 4.8	12.1 ± 3.4	11.6 ± 2.0	53.0 ± 57*	129 ± 86**
Mip-2	20 ± 10	12 ± 5.7	22 ± 17	27.5 ± 18	12.6 ± 1.2	32.2 ± 10.1	63.4 ± 17.4*	170 ± 66**
Kc	4.0 ± 1.5	3.6 ± 1.5	2.7 ± 1.4	16.0 ± 4.8**	4.5 ± 1.8	12.8 ± 6.5**	17.8 ± 2.1**	23.2 ± 11.5**

Expression of mRNA is normalized to 18S rRNA and is multiplied by 10⁷. Mean ± S.D. is shown (n = 3–7). IL-6 data has been published previously [8].
*P < 0.05 versus air-exposed mice.
**P < 0.01 versus air-exposed mice.

ISSN: 1743-8977