Table 3 Inflammatory response in Tnf+/+ and Tnf-/- mice exposed to a single dose of 20 mg/m³ SRM2975

Mice

1 h

1 day

2 days

Tnf +/+

47 ± 15

40 ± 9.3

89 ± 36

74 ± 34

Tnf +/+

1.1 ± 0.8

3.0 ± 1.9

1.3 ± 0.8

1.7 ± 0.7

Tnf -/-

2.5 ± 1.6

4.8 ± 2.8

1.0 ± 0.4

2.6 ± 2.6

Tnf +/+

9.4 ± 2.6

21.9 ± 9.2

9.2 ± 3.9

15.4 ± 3.9

Tnf -/-

14.2 ± 9.1

39.5 ± 29.4

11.4 ± 4.4

33.5 ± 25

Tnf +/+

8.1 ± 0.8

11.9 ± 1.2

19.5 ± 8.2*

12.5 ± 2.6

Tnf -/-

6.6 ± 2.5

10.0 ± 6.8

8.6 ± 2.2

10.4 ± 5.2

Tnf +/+

1.5 ± 0.5

1.9 ± 0.6

2.8 ± 0.8

2.3 ± 1.3

Tnf -/-

1.3 ± 0.9

3.5 ± 2.2

1.5 ± 0.3

2.6 ± 0.7

Tnf +/+

0.2 ± 0.3

0.7 ± 0.3

3.8 ± 4.1**

7.3 ± 5.8**

Tnf -/-

0.4 ± 0.8

1.1 ± 1.3

0.9 ± 0.8

1.5 ± 1.0