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Table 4 Inflammatory response in Tnf+/+ and Tnf-/- mice exposed to multiple doses of 20 mg/m3 SRM2975

From: Cytokine expression in mice exposed to diesel exhaust particles by inhalation. Role of tumor necrosis factor

Marker

Exposure

Air

DEP

 

Mice

Tnf+/+

Tnf-/-

Tnf+/+

Tnf-/-

Tnf

 

6.0 ± 4.4

 

13.8 ± 3.7*

 

Il-6

 

0.6 ± 0.4

1.2 ± 0.6

1.5 ± 0.4*

4.2 ± 1.7**

Mcp-1

 

11.0 ± 6.1

7.5 ± 3.8

17.9 ± 10.3

33.8 ± 16.6**

Mip-2

 

6.5 ± 2.8

5.3 ± 2.5

22.9 ± 13.4**

14.9 ± 7.0**

Kc

 

2.1 ± 1.0

1.2 ± 0.7

2.5 ± 0.8

4.7 ± 2.0**

Neutrophil (%)

 

3.4 ± 6.7

0.2 ± 0.3

12.3 ± 7.9**

16.5 ± 10.1**

  1. Expression of mRNA is normalized to 18S rRNA and is multiplied by 107. Mean ± S.D. is shown (n = 7–8). Neutrophil, TNF and IL6 data has been published previously [7].
  2. *P < 0.05 versus air-exposed mice. **P < 0.01 versus air-exposed mice.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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