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Table 6 Results of bacterial gene point mutation assay. Cerium oxide - nanoparticulate. Summary of mean revertant colonies obtained

From: Initial in vitro screening approach to investigate the potential health and environmental hazards of Envirox™ – a nanoparticulate cerium oxide diesel fuel additive

Experiment 1
   TA100 TA1535 TA102 TA98 TA1537
Substance Dose Level (μg/plate) Mean ± S.D. Mean ± S.D. Mean ± S.D. Mean ± S.D. Mean ± S.D.
   (-S9) (+S9) (-S9) (+S9) (-S9) (+S9) (-S9) (+S9) (-S9) (+S9)
DMSO 100 μl 118 ± 7 97 ± 13 39 ± 3 32 ± 6 347 ± 29 351 ± 4 28 ± 3 36 ± 7 13 ± 5 22 ± 2
Cerium Oxide Nano 50 100 ± 3 109 ± 17 37 ± 2 29 ± 13 356 ± 10 363 ± 25 23 ± 5 36 ± 2 11 ± 5 18 ± 4
  150 88 ± 13 115 ± 9 40 ± 3 36 ± 1 360 ± 13 381 ± 20 25 ± 6 35 ± 6 12 ± 5 15 ± 5
  500 84 ± 16 114 ± 20 33 ± 3 36 ± 3 377 ± 12 350 ± 17 26 ± 6 35 ± 7 14 ± 5 17 ± 4
  1500 (F) 101 ± 13 115 ± 8 28 ± 4 32 ± 9 343 ± 38 330 ± 17 22 ± 3 35 ± 1 14 ± 4 24 ± 2
  5000 (F+M+P) 101 ± 4 113 ± 7 39 ± 3 38 ± 2 343 ± 16 332 ± 14 23 ± 4 37 ± 4 12 ± 2 20 ± 5