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Table 6 Results of bacterial gene point mutation assay. Cerium oxide - nanoparticulate. Summary of mean revertant colonies obtained

From: Initial in vitro screening approach to investigate the potential health and environmental hazards of Envirox™ – a nanoparticulate cerium oxide diesel fuel additive

Experiment 1

  

TA100

TA1535

TA102

TA98

TA1537

Substance

Dose Level (μg/plate)

Mean ± S.D.

Mean ± S.D.

Mean ± S.D.

Mean ± S.D.

Mean ± S.D.

  

(-S9)

(+S9)

(-S9)

(+S9)

(-S9)

(+S9)

(-S9)

(+S9)

(-S9)

(+S9)

DMSO

100 μl

118 ± 7

97 ± 13

39 ± 3

32 ± 6

347 ± 29

351 ± 4

28 ± 3

36 ± 7

13 ± 5

22 ± 2

Cerium Oxide Nano

50

100 ± 3

109 ± 17

37 ± 2

29 ± 13

356 ± 10

363 ± 25

23 ± 5

36 ± 2

11 ± 5

18 ± 4

 

150

88 ± 13

115 ± 9

40 ± 3

36 ± 1

360 ± 13

381 ± 20

25 ± 6

35 ± 6

12 ± 5

15 ± 5

 

500

84 ± 16

114 ± 20

33 ± 3

36 ± 3

377 ± 12

350 ± 17

26 ± 6

35 ± 7

14 ± 5

17 ± 4

 

1500 (F)

101 ± 13

115 ± 8

28 ± 4

32 ± 9

343 ± 38

330 ± 17

22 ± 3

35 ± 1

14 ± 4

24 ± 2

 

5000 (F+M+P)

101 ± 4

113 ± 7

39 ± 3

38 ± 2

343 ± 16

332 ± 14

23 ± 4

37 ± 4

12 ± 2

20 ± 5