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Figure 3 | Particle and Fibre Toxicology

Figure 3

From: Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction

Figure 3

Histopathologic alterations were subtle in the lungs of rats inhaling fine TiO 2 . These changes principally consisted of particle accumulation. Particles were difficult to see using transmitted light (A) but were birefringent when visualized using cross-polarized light, enhancing their detection (B). The particle accumulation included apparently free TiO2 particles (open arrow), TiO2 particles within morphologically normal alveolar macrophages (dashed arrows), and TiO2 particles within macrophages without nuclei (anuclear macrophages, solid arrows). Both morphologically normal and anuclear macrophages were frequently in contact with the alveolar wall. H&E section. Reference bar = 20 μm.

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