Figure 4
From: Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction
Histopathologic alterations were particularly subtle in the lungs of rats inhaling ultrafine TiO 2 . Ultrafine particle accumulation in alveolar macrophages (arrows) was difficult to see with transmitted light (A). Ultrafine particle accumulation within alveolar macrophages was more easily visualized as birefringent intracytoplasmic material using cross-polarized light (B). Macrophages containing ultrafine TiO2 particles were frequently in contact with the alveolar wall. H&E section. Reference bar = 20 μm.