Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume

Table 1 Bronchoalveolar lavage parameters 2 days post-exposure

Mouse Strain	n	Exposure	%Albumin^§	%LDH^§	%Lymphocytes^\|\|	%PMN^\|\|
A/J	7	GMA-MS	126 ± 4	155 ± 7*	0.8 ± 0.4 (0.2 ± 0.13)	24 ± 3*^‡ (1.1 ± 1.1)
C57BL/6J	7	GMA-MS	109 ± 3	134 ± 10*	1.3 ± 0.8 (0.3 ± 0.1)	12 ± 3* (0.05 ± 0.05)
A/J	7	GMA-SS	229 ± 13*^†‡	307 ± 12*^†‡	2.2 ± 0.8*^† (0.2 ± 0.13)	44 ± 3*^†‡ (1.1 ± 1.1)
C57BL/6J	6	GMA-SS	139 ± 13*^†	176 ± 16*	2.1 ± 0.2* (0.3 ± 0.1)	9 ± 2* (0.05 ± 0.05)
A/J	7	MMA-SS	331 ± 26*^†‡	343 ± 33*^†‡	0.1 ± 0.06 (0.06 ± 0.06)	41 ± 4*^†‡ (0.7 ± 0.6)
C57BL/6J	7	MMA-SS	218 ± 16*	230 ± 25*	1.6 ± 0.24*^‡ (0 ± 0)	9 ± 2* (0.2 ± 0.08)
A/J	7	S-Cr	209 ± 10*	178 ± 14*	0.5 ± 0.16*^† (0.06 ± 0.06)	11 ± 0.8* (0.7 ± 0.6)
C57BL/6J	7	S-Cr	266 ± 25*^†‡	182 ± 20*	2 ± 0.6*^‡ (0 ± 0)	9 ± 3* (0.2 ± 0.08)

*Significantly different from corresponding sham; ^†Between exposed groups of the same mouse strain; ‡Between mouse strains of the same exposure group (p < 0.05)
^§LDH and albumin data are represented as % corresponding sham.
^||Percentage from a differential cell count of > 300 cells with the corresponding sham % in parentheses. Note. Data are means ± SE. Statistical comparisons were MMA-SS and S-Cr or GMA-MS and GMA-SS. Abbreviations are GMA-MS-gas metal arc-mild steel, GMA-SS-gas metal arc stainless steel, or MMA-SS-manual metal arc stainless steel welding fume; S-Cr-soluble chromium VI; LDH-lactate dehydrogenase; PMN-polymorphonuclear leukocytes

ISSN: 1743-8977