Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume

Table 2 Bronchoalveolar lavage parameters 7 days post-exposure

Mouse Strain	n	Exposure	%Albumin^§	%LDH^§	%Lymphocytes^\|\|	%PMN^\|\|
A/J	7	GMA-MS	90 ± 3	156 ± 10*^‡	0.64 ± 0.16 (0 ± 0)	12 ± 1.2*^‡ (0 ± 0)
C57BL/6J	7	GMA-MS	105 ± 3	132 ± 3*	0.54 ± 0.13 (0.14 ± 0.07)	0.72 ± 0.3 (0.05 ± 0.05)
A/J	6	GMA-SS	115 ± 6	216 ± 16* ^†‡	0.86 ± 0.18* (0 ± 0)	20 ± 1.2*^†‡ (0 ± 0)
C57BL/6J	7	GMA-SS	113 ± 4	148 ± 8*	0.8 ± 0.17 * (0.14 ± 0.07)	1.3 ± 0.8 (0.05 ± 0.05)
A/J	7	MMA-SS	145 ± 11*	144 ± 17*	1.8 ± 0.5* (0.1 ± 0.06)	12 ± 1.0*^†‡ (0.1 ± 0.1)
C57BL/6J	7	MMA-SS	115 ± 8	130 ± 5*^†	1.0 ± 0.36* (0 ± 0)	1.6 ± 0.1*^† (0.07 ± 0.07)
A/J	5	S-Cr	137 ± 12*	111 ± 13	2.2 ± 0.46* (0.1 ± 0.06)	5.6 ± 0.6*^‡ (0.1 ± 0.1)
C57BL/6J	7	S-Cr	124 ± 8*	111 ± 7	0.44 ± 0.23 (0 ± 0)	0.22 ± 0.2 (0.07 ± 0.07)

*Significantly different from corresponding sham; ^† Between exposed groups of the same mouse strain; ^‡Between mouse strains of the same exposure group (p < 0.05)
^§LDH and albumin data are represented as % corresponding sham. ^||Percentage from a differential cell count of > 300 cells with the corresponding sham % in parentheses.
Note. Data are means ± SE. Statistical comparisons were MMA-SS and S-Cr or GMA-MS and GMA-SS. Abbreviations are GMA-MS-gas metal arc-mild steel, GMA-SS-gas metal arc stainless steel, or MMA-SS-manual metal arc stainless steel welding fume; S-Cr-soluble chromium VI; LDH-lactate dehydrogenase; PMN-polymorphonuclear leukocytes

ISSN: 1743-8977