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Table 4 Lung histopathology for A/J mice 48 and 78 Weeks post-exposure

From: Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume

  Exposure n Lymphoid Infiltrates* Welding Fume-Laden Cells Lung Tumor Multiplicity Lung Tumor Incidence
48 wk Sham 21 1.08 ± 0.16 0 ± 0 0.55 ± 0.14 50%
  GMA-MS 24 0.30 ± 0.10 0.34 ± 0.10§ 0.38 ± 0.12 33%
  GMA-SS 20 1.23 ± 0.22 3.03 ± 0.13§ 0.75 ± 0.15    65%**
  MMA-SS 24 0.90 ± 0.16 0.67 ± 0.13§ 0.38 ± 0.12 33%
78 wk Sham 19 1.53 ± 0.29 0 ± 0 1.47 ± 0.33 68%
  GMA-MS 20 0.78 ± 0.24 0.15 ± 0.07§ 1.40 ± 0.32 75%
  GMA-SS 16 2.53 ± 0.36§ 1.12 ± 0.17§ 1.94 ± 0.38 88%
  MMA-SS 20 1.70 ± 0.27 0.55 ± 0.19§ 1.85 ± 0.46 75%
  1. *Perivascular/peribronchial associated lymphocytes, macrophages, and plasma cells.
  2. Average number of tumors/preneoplastic lesions per lung, includes mice with no lesions.
  3. Percentage of tumor/preneoplasia-bearing mice out of the total. §Significantly increased compared to sham (p < 0.05). ||Significantly increased compared to GMA-MS and MMA-SS welding fumes (p < 0.05). **Significantly increased versus GMA-MS (p ≤ 0.05).
  4. Note: Abbreviations are GMA-MS-gas metal arc-mild steel, GMA-SS-gas metal arc stainless steel, or MMA-SS-manual metal arc stainless steel welding fume. Data are mean ± SE.