A comparison of cellular cytotoxicity elicited in animals receiving various mass doses of UFTiO
suspended in BALF. A comparison of cellular cytotoxicity elicited in animals receiving various mass doses of UFTiO2 and FTiO2 suspended in BALF at 1 day (Panel A), 7 days (Panel B), and 42 days (Panel C) post-exposure. Rats were exposed to various mass doses of UFTiO2 and FTiO2 by intratracheal instillation. Animals were euthanized at 1 day, 7 days, and 42 days post-exposure and bronchoalveolar lavage was performed. Cytotoxicity was assessed by measuring LDH activity. Values are increase in LDH activity above the BALF control and are given as means ± SE of 8 experiments. Control values of LDH activity were 46.375 ± 2.24, 39.5 ± 1.35, and 37.25 ± 2.63 U/l for 1, 7 and 42 days, respectively. Linear regression analysis with a 95% confidence interval reveals that on a mass dose basis UFTiO2 causes significantly more LDH activity than FTiO2 at all post-exposure time points. * indicates a significant increase from control (p < 0.05; ANOVA).