A comparison of cellular damage elicited in animals receiving various mass doses of UFTiO
suspended in BALF. A comparison of cellular damage elicited in animals receiving various mass doses of UFTiO2 and FTiO2 suspended in BALF at 1 day (Panel A), 7 days (Panel B), and 42 days (panel C) post-exposure. Rats were exposed to various mass doses of UFTiO2 and FTiO2 by intratracheal instillation. Animals were euthanized at 1 day, 7 days, and 42 days post-exposure and bronchoalveolar lavage was performed. Cellular injury was assessed by measuring albumin levels. Control values of albumin levels were 0.073 ± 0.033, 0.084 ± 0.003, 0.098 ± 0.007 mg/ml for 1, 7, and 42 days, respectively. Values are increase in albumin levels above the BALF control and are given as means ± SE of 8 experiments. * indicates a significant increase from control (p < 0.05; ANOVA).