Skip to main content

Table 1 Potency difference between UFTiO2 and FTiO2 when analyzed on a mass vs. surface area basis.

From: Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area

Parameter Dose Metric 1 Day 7 Days 42 Days
PMN (106)     
  Mass 41 41 41
  Surface Area 2 1.3 1.6
LDH (U/l)     
  Mass 41 30 41
  Surface Area 1.2 1.2 1.8
Albumin     
  Mass 82 41 41
  Surface Area 3 1.4 2
TNF-α (pg/ml)     
  Mass 41 41 41
  Surface Area 1.2 1.4 1.5
MIP-2 (pg/ml)     
  Mass 41 41 82
  Surface Area 1.2 1.1 1.1
IL-1β (pg/ml)     
  Mass 82 82 82
  Surface Area 1.6 1.8 1.4
Zym. Stim. Chemi.     
  Mass 82 82 82
  Surface Area 1.75 1.8 3
NO Dep. Chemi.     
  Mass 41 82 82
  Surface Area 1.5 7 8
  1. Comparison of UFTiO2 and FTiO2 potency differences. The data were analyzed to show the potency difference between UFTiO2 and FTiO2 on a mass basis as well as the fold increase in pulmonary toxicity response on a surface area basis. All post-exposure time points were analyzed and are reported in the table. On a mass basis, the UFTiO2 has much greater potency than FTiO2, but when dose is normalized to total particle surface area administered the fold increase in response between the UFTiO2 and FTiO2 is greatly reduced.