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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Exposure to ultrafine carbon particles at levels below detectable pulmonary inflammation affects cardiovascular performance in spontaneously hypertensive rats

Figure 4

Changes in the lung and heart transcript levels of haemoygenase-1 (HO-1; a), endothelin-1 (ET-1; b), endothelin receptor A (ETA; c), endothelin receptor B (ETB; d), plasminogen activator inhibitor-1 (PAI-1; e) and tissue factor (TF; f) in control (filtered air) and ultrafine carbon particles (UfCPs) exposed SHRs on the first and third recovery day. Real time qRT-PCR was performed and the comparative CT method was used for the quantification of fold change. Bars represent arithmetic mean values ± SE of control (white bars; n = 6) and UfCPs exposed SHRs on first (light gray bars; n = 6) and third recovery day (dark gray bars; n = 6). Lung expression of all other markers (except PAI-1) was not affected on the first day of recovery (light gray) – but showed significant inductions on the third day of recovery (dark gray) by factors of about 2.5, except for ET-1 which increased about 6-fold. *: Significant (p < 0.05) difference in expression level between exposed animals compare to the corresponding control: †: Significant (p < 0.05) difference in expression level between exposed SHRs on first (light gray) and third (dark gray) recovery day.

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