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Table 1 DNA damage in A549 cells exposed to authentic street particulate matter for 24 hours.

From: DNA damage and cytotoxicity in type II lung epithelial (A549) cell cultures after exposure to diesel exhaust and urban street particles

Filtera

Dose (μg/ml)

 

Control

2.5

25

100

Filter 1

    

   SB

0.143 ± 0.0208

0.122 ± 0.0185

0.411 ± 0.134

0.481 ± 0.149

   FPG

0.069 ± 0.0452

0.066 ± 0.0286

0.205 ± 0.0690

0.191 ± 0.0488

Filter 2

    

   SB

0.104 ± 0.00134

0.090 ± 0.00314

0.122 ± 0.0207

0.201 ± 0.0233

   FPG

0.106 ± 0.0196

0.041 ± 0.0160

0.101 ± 0.0386

0.148 ± 0.0338

Filter 3

    

   SB

0.116 ± 0.00947

0.097 ± 0.0160

0.352 ± 0.134

0.308 ± 0.0566

   FPG

0.087 ± 0.0466

0.104 ± 0.0213

0.175 ± 0.0376

0.305 ± 0.0888

Filter 4

    

   SB

0.104 ± 0.0134

0.089 ± 0.0153

0.127 ± 0.0110

0.453 ± 0.178

   FPG

0.106 ± 0.0196

0.076 ± 0.0253

0.102 ± 0.0177

0.210 ± 0.0522

Filter 5

    

   SB

0.150 ± 0.00919

0.197 ± 0.0415

0.218 ± 0.0395

0.399 ± 0.0309b

   FPG

0.289 ± 0.0266

0.513 ± 0.0552

0.415 ± 0.0584

0.621 ± 0.0276b

All filters

    

   SB

0.123 ± 0.00975

0.119 ± 0.0204

0.246 ± 0.0586

0.368 ± 0.0512c

   FPG

0.131 ± 0.0400

0.160 ± 0.0888

0.200 ± 0.0575

0.295 ± 0.0853c

  1. a The data from filter 1–5 represent lesions/106 bp as mean ± SEM, n = 6.
  2. b Statistical significant compared to the control, p < 0.05 (Kruskal-Wallis test), Ntotal = 24.
  3. c Statistical significant compared to the control, p < 0.05 (randomized block ANOVA), the statistical analysis was based on the mean value of each filter (Ntotal = 20).
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Particle and Fibre Toxicology

ISSN: 1743-8977

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