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Table 1 Immunoractivity of investigated antibodies in 15 Air and DE paired subjects participated in study.

From: Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium

Immunoreactivity Air Diesel p value
EGFR 0.240 (0.100–0.370) 0.690 (0.210–1.960) p = 0.004
Tyr 845 0.220 (0.027–0.520) 0.460 (0.160–1.030) p = 0.1
Tyr 992 0.450 (0.320–0.580) 0.530 (0.220–1.540) p = 0.14
Tyr 1068 0.015 (0.002–0.250) 0.180 (0.013–0.550) p = 0.18
Tyr 1110 1.090 (0.560–2.140) 1.780 (0.980–2.200) p = 0.39
Tyr 1173 2.230 (1.380–2.890) 3.160 (1.800–5.070) p = 0.02
Tyr 416 0.033 (0.001–0.120) 0.016 (0.003–0.800) p = 0.13
MEK 1, 2 1.330 (0.310–2.670) 1.410 (0.630–4.440) p = 0.28
ERK 1, 2 0.140 (0.024–0.320) 0.160 (0.045–0.650) p = 0.14
  1. Two sections from each biopsy and exposure were evaluated during investigation of each antibody.
  2. Bronchial epithelium expression of EGFR, Tyrosine sites and downstream signalling immunoreactivity is given as percentage (%) positively stained area of the total measured epithelial area. All values are quoted as medians with inter-quartile range. Statistical comparisons by Wilcoxon's paired rank test.