The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles

Table 1 Particle-specific adverse health effects of the 3 particle types under consideration.

	Adverse effects
Particle	Pulmonary	Extra-pulmonary
Asbestos	Interstitial fibrosis, bronchogenic carcinoma, pleural mesothelioma, pleural fibrosis, pleural plaques	Peritoneal mesothelioma, Autoimmune disease
Quartz	Nodular fibrosis, small airways disease, bronchogenic carcinoma, pleural fibrosis	Autoimmune disease
PM₁₀	Increased lung cancer risk Exacerbations of COPD, Development of COPD Exacerbations of asthma	Deaths and hospitalisations for cardiovascular disease,

ISSN: 1743-8977