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Table 2 Studies showing significant effects of the different particle types on inflammatory, genotoxic and oxidative stress endpoints in vitro

From: The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles

 

Endpoint

Particle

Oxidative stress

NF-κB activation

AP-1 Activation

Chemokine production epithelial cells

TNFα production macs

Growth factor production

Direct genotox-icity

Apoptosis

Asbestos

[21]

[4]

[23]

[16]

[8]

[14] fibroblasts

[15]

[3]

Quartz

[9]

[17]

[18]

[20]

[6]

[24] epithelial cells

[35]

[12]

PM10

[19]

[13]

[22]

[65]

[5]

[7] epithelial cells

[11]

[10]