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Figure 3 | Particle and Fibre Toxicology

Figure 3

From: Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide

Figure 3

Comparison of inflammatory potential of low, medium and high doses of UFTiO 2 (Panel A) and UFCB (Panel B) at the various post-exposure time points. A comparison of inflammatory potential of low, medium and high doses of UFTiO2 (Panel A) and UFCB (Panel B) at the various post-exposure time points. Rats were exposed to various mass doses of UFTiO2 (0.26, 0.52 and 1.04 mg/rat) and UFCB (0.047, 0.094, and 0.188 mg/rat) by intratracheal instillation. These mass doses resulted in identical surface area doses (0.0313, 0.0625, and 0.125 cm2/cm2) of UFTiO2 and UFCB. Animals were euthanized at 1 day, 7 days, and 42 days post-exposure and bronchoalveolar lavage was conducted. Inflammation was assessed by measuring PMN levels. Control PMN values were 1.37 × 106, 0.78 ± 0.074 × 106, 0.88 ± 0.095 × 106 cells/rat for the UFTiO2 study and 1.45 ± 0.22 × 106, 1.09 ± 0.14 × 106, and 1.01 ± 0.14 × 106 cells/rat for the UFCB study at 1, 7 and 42 days, respectively. Values are the increases in PMN number above BALF control and are given as means ± SEM of 8 rats. * indicates that PMN levels for that group were significantly higher than control (p < 0.05) using ANOVA.

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