From: Mesothelioma: Do asbestos and carbon nanotubes pose the same health risk?
Cell/tissue response | Comparison |
---|---|
Particle uptake | Demonstrated with both types. Conflicting results with CNTs. Exocytosis found with CNTs, so far not investigated with asbestos. |
Cytotoxicity | Both cytotoxic. |
DNA damage, mutation, gene interaction | Found with both asbestos and CNTs. |
Transfection | Gene transfer is with asbestos. CNT gene knockdown. |
Biodistribution | Both types are cleared via the lymphatic system and found in different organs |
Inflammation, granulomas, fibrosis | Found with both asbestos and CNTs. Both types show dependence of biological effects with fibre dimensions: bioactivity of long fibres. |
Cancer | MM found with both asbestos and CNTs by peritoneal exposure. |