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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Coal dust alters β-naphthoflavone-induced aryl hydrocarbon receptor nuclear translocation in alveolar type II cells

Figure 4

Morphometric quantification of AhR in the nucleus and cytoplasm of isolated AT-II cells. (A) The proportional AhR in the nucleus was significantly increased (letter a; p < 0.05) in the saline plus BNF group compared to the saline plus oil group but no increase in nuclear AhR was observed after BNF in co-treated rats. (B) No significant change in the proportional AhR expression in cytoplasm of rats receiving BNF compared to those receiving oil was observed in either the IT saline or CD groups. (C) The percentage of AT-II cells with AhR localized in the nucleus was significantly increased (letter a; p < 0.05) in BNF-exposed rats without CD exposure but not in BNF and CD exposed rats. (D) The proportional AhR expression in AT-II cell cytosol was significantly higher (P < 0.05) than that in the nucleus in all treatment groups (letters e, f, g, and h, respectively). (E) The total area of AhR expression per AT-II cell was significantly increased (p < 0.05) in rats receiving saline plus BNF compared to those receiving saline plus oil (letter a; p < 0.05) but BNF causes no changes in rats receiving CD. Results are mean + SE, n = 4 in all groups except in saline plus oil group (n = 3).

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