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Figure 7 | Particle and Fibre Toxicology

Figure 7

From: Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems

Figure 7

Microscopic findings in lungs of gpt delta mice intratracheally instilled with particles. Normal appearance of pulmonary parenchyma in a vehicle-control (Panel A). Pulmonary parenchyma obtained from gpt delta mice intratracheally instilled with four consecutive doses of 0.2 mg/mice of C60 (Panel B), CB (Panel C) and kaolin (Panel D). Test substance-phagocytized macrophages (arrowheads) can be observed, and granulomaous (arrows) formations are also found in lungs of particle-instilled mice. A-D; Original magnification × 40.

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