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Table 3 Animal studies evaluating the effect of air pollution on atherosclerosis

From: Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress

Study PM fraction (mode of administration) Animal model Diet Assessment of Atherosclerosis (Method) Effect on atherosclerosis Reference
Suwa et al
2002
PM10 (I.T.) Watanabe rabbits Chow % lesional volume in coronary arteries and aorta (histology) Increase [38]
Chen & Nadziejko
2005
PM2.5
(Inhaled CAPs)
apoE-/-, LDL-/- mice
apoE-/- mice
Chow
Chow
% lesional area in whole aorta (histology) No change
Increase
[41]
Sun et al 2005 PM2.5
(Inhaled CAPs)
apoE-/- mice Chow
HFD
% lesional area in cross-sections of aorta (histology) N.S. increase
Increase
[42]
Sun et al
2008
PM2.5
(Inhaled CAPs)
apoE-/- mice Chow
HFD
% lesional area in aorta (ultrasound) N.S. increase
Increase
[43]
Araujo et al
2008
PM2.5 & UFP (Inhaled CAPs) apoE-/-mice Chow
Chow
Mean lesional area in aortic root (histology) N.S. increase
Increase
[44]
  1. I.T. = Intratraqueal, CAPs = Concentrated ambient particles, HFD = High fat diet, N.S. = Not significant