From: Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress
Study | PM fraction (mode of administration) | Animal model | Diet | Assessment of Atherosclerosis (Method) | Effect on atherosclerosis | Reference |
---|---|---|---|---|---|---|
Suwa et al 2002 | PM10 (I.T.) | Watanabe rabbits | Chow | % lesional volume in coronary arteries and aorta (histology) | Increase | [38] |
Chen & Nadziejko 2005 | PM2.5 (Inhaled CAPs) | apoE-/-, LDL-/- mice apoE-/- mice | Chow Chow | % lesional area in whole aorta (histology) | No change Increase | [41] |
Sun et al 2005 | PM2.5 (Inhaled CAPs) | apoE-/- mice | Chow HFD | % lesional area in cross-sections of aorta (histology) | N.S. increase Increase | [42] |
Sun et al 2008 | PM2.5 (Inhaled CAPs) | apoE-/- mice | Chow HFD | % lesional area in aorta (ultrasound) | N.S. increase Increase | [43] |
Araujo et al 2008 | PM2.5 & UFP (Inhaled CAPs) | apoE-/-mice | Chow Chow | Mean lesional area in aortic root (histology) | N.S. increase Increase | [44] |