Skip to main content
Figure 3 | Particle and Fibre Toxicology

Figure 3

From: Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice

Figure 3

Time course response markers (categories 2A and 2B) in the lung homogenate following intratracheal (i.t.) instillation of carbon nanoparticles (CNP) in C3H/HeJ (C3) mice. (n = 4 animals/experimental group). (a-r) lists the markers which showed a typical dose response but remained at elevated levels (not significantly different compared to 20 μg/day 1) even after day 7 following a significant induction at day 1 due to 20 μg i.t. instillation of CNP. At day 7 neutrophil influx related inflammation was completely resolved. Gene symbols are used as shown in additional file 1; Table S1. (**) Significantly different with respect to (w.r.t) both scham (Sham) control and 5 μg exposed; (*): Significantly different w.r.t scham control or 5 μg exposed; (†) significantly different w.r.t 20 μg exposed at day 1; (††) significantly different w.r.t 20 μg at day 1, 5 μg and sham control.

Back to article page

Particle and Fibre Toxicology

ISSN: 1743-8977

Contact us