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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Soluble iron modulates iron oxide particle-induced inflammatory responses via prostaglandin E2 synthesis: In vitro and in vivo studies

Figure 4

Injury markers in BALF of rat lungs after instillation of 1.5 and 0.5 μm Fe 2 O 3 particles ( in vivo study). Healthy WKY rats were intratracheally instilled with 1.5 μm or 0.5 μm Fe2O3 particles, respectively, at a dose of 1.3 mg/kg body weight and 4.0 mg/kg body weight. At 24 h after instillation pulmonary injury was assessed in the BALF of control and exposed rats. Protein (A) and albumin levels (B) in BALF were determined as markers for vascular permeability, and LDH activity (C) as marker for cytotoxicity. The data are given as mean ± SD with (n = 6) representing 6 animals for each dose and type of particles. * P-value (> 0.05) for significant difference between saline control and Fe2O3 particle exposed rats.

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