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Figure 6 | Particle and Fibre Toxicology

Figure 6

From: Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation

Figure 6

PCR validation of Time effects. Real-time PCR was used to measure expression of select probes chosen from the list of differentially expressed genes according to factor Time (FDR adjP < 0.05). Values represent geometric mean ± SD (n = 5 animals/group). Units are arbitrary. Measurements for naïve animals (n = 4/genotype) are included to facilitate interpretation of effects. The microarray data (the ratio of 0 h/24 h expression and the associated FDR-adjusted p-value) are displayed below each graph for comparison. A) Metallothionein-II. Time main effect, p < 0.001; Genotype main effect, p = 0.003; Treatment main effect, p = 0.03. B) Platelet-derived growth factor (PDGF)-α. Time main effect, p < 0.001. Genotype main effect, p < 0.001. C) Angiopoietin-like 4. Time main effect, p < 0.001; Genotype main effect, p < 0.001. Asterisks denote statistical significance (Holm-Sidak, p < 0.05). * 0 vs. 24 h within Time; ** WT vs. TNF within Genotype; *** Air vs. EHC within Treatment.

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