Skip to main content

Table 2 Functional analysis of probes that differ according to factor Genotype.*

From: Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation

Functional term Number of genes % of total P-value
immune system process 167 9.12% 4.19 × 10-27
antigen processing and presentation 34 1.86% 1.61 × 10-15
cell activation 56 3.06% 4.48 × 10-9
response to wounding 66 3.60% 4.55 × 10-9
leukocyte activation 53 2.89% 6.90 × 10-9
defence response 81 4.42% 3.19 × 10-9
response to external stimulus 87 4.75% 3.48 × 10-8
cytoskeleton organization and biogenesis 87 4.75% 6.72 × 10-8
hemopoietic or lymphoid organ development 54 2.85% 5.14 × 10-7
inflammatory response 47 2.57% 1.28 × 10-6
taxis 29 1.58% 4.19 × 10-6
mast cell activation 9 0.49% 1.45 × 10-5
lysosome organization and biogenesis 9 0.49% 2.83 × 10-5
cell division 44 2.40% 8.12 × 10-5
  1. * DAVID functional annotation analysis http://david.abcc.ncifcrf.gov/home.jsp was carried out using the list of the genes responding according to factor Genotype common to all treatment groups (1864 probes; 1831 unique DAVID IDs), with the Agilent Mouse Microarray G4121A probe list serving as background. Representative enriched terms selected from the top 50 of 278 gene ontology terms with a modified Fisher's Exact p < 0.05 are displayed.