Skip to main content
Figure 1 | Particle and Fibre Toxicology

Figure 1

From: NF-κB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells

Figure 1

In vivo NF-κB activation and expression of inflammation-related genes in quartz-instilled rats, 3 days post-exposure. A. Representative immunohistochemistry of lung tissue sections from rats instilled with DQ12 quartz or PBS. Dark brown staining indicates Ser32/36 phospho-IκBα, blue/purple staining indicates cell nuclei. Short arrows point out alveolar epithelial type II cells, alveolar macrophages are designated by the longer arrow. Original magnification: 1000×. B. In vivo expression of iNOS, HO-1 and COX-2 in lung tissue homogenates measured by qRT-PCR. Data are expressed as fold induction compared to control animals and are corrected for expression of the housekeeping gene HPRT. *P < 0.05 vs. control animals (n = 3/group).

Back to article page