Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust

Table 1 Fibrin clot structure in young, healthy volunteers exposed to filtered air and diesel exhaust

						P values for comparison of changes between filtered air and diesel exhaust
	Pre-exposed	2 hr	6 hr	Δ 2 hr	Δ 6 hr	Δ 2 hr	Δ 6 hr
Filtered air (n = 16)
Ks (×10 ^-9 cm ² )	5.17 ± 1.48	5.27 ± 2.64	5.13 ± 1.22	0.10 ± 2.01	-0.04 ± 0.92	-	-
ODmax	0.230 ± 0.051	0.255 ± 0.078	0.233 ± 0.059	0.025 ± 0.042	0.003 ± 0.021	-	-
Lag time (seconds)	917 ± 321	906 ± 352	922 ± 482	-11 ± 302	5 ± 385	-	-
Fibre Diameter (nm)	458 ± 18	457 ± 18	470 ± 25	-1 ± 18	12 ± 24	-	-
Fibre Density (fibres/120 μm)	7.3 ± 1.6	7.5 ± 1.6	7.2 ± 1.8	0.2 ± 1.1	-0.1 ± 2.1	-	-
Fibrinogen level (mg/ml)	2.05 ± 0.43	2.12 ± 0.43	1.81 ± 0.31	0.07 ± 0.48	-0.24 ± 0.36	-	-
Diesel Exhaust (n = 15)
Ks (× 10 ^-9 cm ² )	4.94 ± 1.89	5.44 ± 1.46	4.85 ± 1.26	0.51 ± 1.95	-0.09 ± 1.32	0.55	0.90
ODmax	0.246 ± 0.044	0.244 ± 0.039	0.238 ± 0.039	-0.002 ± 0.024	-0.008 ± 0.036	0.03§	0.17
Lag time (seconds)	846 ± 223	788 ± 226	737 ± 201	-58 ± 270	-109 ± 226	0.64	0.56
Fibre Diameter (nm)	455 ± 21	459 ± 16	465 ± 21	4 ± 21.7	10 ± 24.4	0.54	0.91
Fibre Density (fibres/120 μm)	7.8 ± 1.4	8.1 ± 1.7	8.1 ± 1.7	0.3 ± 1.2	0.3 ± 1.2	0.97	0.59
Fibrinogen level (mg/ml)	2.10 ± 0.45	2.08 ± 0.41	1.96 ± 0.22	-0.02 ± 0.33	-0.14 ± 0.32	0.76	0.26

Data represents before exposure (pre-exposed), 2 hours after exposure (2 hr), 6 hours after exposure (6 hr), the difference between 2 hours and pre-exposed (Δ 2 hr) and the difference between 6 hours and pre-exposed (Δ 6 hr). The values are mean ± standard deviation. P values were calculated by paired t-test.
Bold typeset indicates values that were significantly different from baseline.
§ indicates the changes after diesel exhaust exposure were significantly different from those after filtered air exposure.

ISSN: 1743-8977