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Table 2 Relative organ weights for female rats after 90-day oral administration of silver nanoparticles (mean ± S.D., n≥9)

From: Subchronic oral toxicity of silver nanoparticles

  Dose (mg/Kg)
  0 30 125 500
Ovary (Left) 0.027 ± 0.004 0.026 ± 0.005 0.023 ± 0.003 0.024 ± 0.007
Ovary (Right) 0.072 ± 0.134 0.025 ± 0.006 0.026 ± 0.003 0.028 ± 0.005
Spleen 0.22 ± 0.02 0.21 ± 0.01 0.21 ± 0.01 0.21 ± 0.02
Liver 2.67 ± 0.18 2.61 ± 0.07 2.53 ± 0.12 2.62 ± 0.17
Pituitary gland 0.007 ± 0.002 0.006 ± 0.002 0.006 ± 0.001 0.007 ± 0.002
Adrenal gland (Left) 0.015 ± 0.003 0.014 ± 0.002 0.014 ± 0.001 0.015 ± 0.003
Adrenal gland (Right) 0.014 ± 0.001 0.014 ± 0.002 0.014 ± 0.002 0.015 ± 0.001
Uterus 0.233 ± 0.044 0.257 ± 0.090 0.216 ± 0.040 0.195 ± 0.040
Lungs 0.54 ± 0.06 0.55 ± 0.04 0.50 ± 0.05 0.54 ± 0.05
Brain 0.99 ± 0.05 0.98 ± 0.05 0.99 ± 0.06 1.00 ± 0.05
Heart 0.32 ± 0.02 0.32 ± 0.02 0.31 ± 0.02 0.32 ± 0.03
Thymus 0.14 ± 0.02 0.13 ± 0.02 0.13 ± 0.02 0.15 ± 0.02
Kidney (Left) 0.31 ± 0.02 0.30 ± 0.02 0.30 ± 0.01 0.30 ± 0.02
Kidney (Right) 0.31 ± 0.02 0.29 ± 0.01* 0.30 ± 0.01* 0.30 ± 0.02
  1. *Significant difference vs. control, p < 0.05