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Table 2 Relative organ weights for female rats after 90-day oral administration of silver nanoparticles (mean ± S.D., n≥9)

From: Subchronic oral toxicity of silver nanoparticles

 

Dose (mg/Kg)

 

0

30

125

500

Ovary (Left)

0.027 ± 0.004

0.026 ± 0.005

0.023 ± 0.003

0.024 ± 0.007

Ovary (Right)

0.072 ± 0.134

0.025 ± 0.006

0.026 ± 0.003

0.028 ± 0.005

Spleen

0.22 ± 0.02

0.21 ± 0.01

0.21 ± 0.01

0.21 ± 0.02

Liver

2.67 ± 0.18

2.61 ± 0.07

2.53 ± 0.12

2.62 ± 0.17

Pituitary gland

0.007 ± 0.002

0.006 ± 0.002

0.006 ± 0.001

0.007 ± 0.002

Adrenal gland (Left)

0.015 ± 0.003

0.014 ± 0.002

0.014 ± 0.001

0.015 ± 0.003

Adrenal gland (Right)

0.014 ± 0.001

0.014 ± 0.002

0.014 ± 0.002

0.015 ± 0.001

Uterus

0.233 ± 0.044

0.257 ± 0.090

0.216 ± 0.040

0.195 ± 0.040

Lungs

0.54 ± 0.06

0.55 ± 0.04

0.50 ± 0.05

0.54 ± 0.05

Brain

0.99 ± 0.05

0.98 ± 0.05

0.99 ± 0.06

1.00 ± 0.05

Heart

0.32 ± 0.02

0.32 ± 0.02

0.31 ± 0.02

0.32 ± 0.03

Thymus

0.14 ± 0.02

0.13 ± 0.02

0.13 ± 0.02

0.15 ± 0.02

Kidney (Left)

0.31 ± 0.02

0.30 ± 0.02

0.30 ± 0.01

0.30 ± 0.02

Kidney (Right)

0.31 ± 0.02

0.29 ± 0.01*

0.30 ± 0.01*

0.30 ± 0.02

  1. *Significant difference vs. control, p < 0.05