Skip to main content

Table 4 Serum values for female rats after 90-day oral administration of silver nanoparticles (mean ± S.D.)

From: Subchronic oral toxicity of silver nanoparticles

 

Dose (mg/Kg)

 

0 (n = 10)

30 (n = 9)

125 (n = 10)

500 (n = 10)

ALB

2.78 ± 0.08

2.73 ± 0.10

2.75 ± 0.24

2.63 ± 0.09

ALP

237.50 ± 29.05

241.22 ± 22.12

253.50 ± 25.42

314.80 ± 42.13**

CA

10.42 ± 0.60

10.11 ± 0.26

10.08 ± 0.30

9.98 ± 0.27

CHO

107.50 ± 7.35

115.11 ± 12.36

116.30 ± 6.95

126.70 ± 12.39**

CRE

0.85 ± 0.16

0.96 ± 0.15

0.91 ± 0.10

0.90 ± 0.13

GGT

0.80 ± 0.42

1.11 ± 0.78

0.90 ± 0.57

0.80 ± 0.63

GLU

148.70 ± 20.09

146.33 ± 14.53

151.20 ± 16.48

151.30 ± 20.19

AST

94.80 ± 11.98

84.22 ± 23.82

84.20 ± 6.89

94.80 ± 38.14

ALT

67.70 ± 6.00

59.78 ± 10.57

61.10 ± 5.15

70.90 ± 22.00

LDH

722.00 ± 480.71

705.33 ± 612.27

496.90 ± 303.14

516.90 ± 245.26

MG

2.44 ± 0.17

2.30 ± 0.24

2.17 ± 0.08**

2.18 ± 0.15**

TP

6.30 ± 0.17

6.14 ± 0.22

6.08 ± 0.14*

6.03 ± 0.23*

UA

1.12 ± 0.39

0.97 ± 0.31

0.86 ± 0.19

0.87 ± 0.12

BUN

23.61 ± 2.57

22.26 ± 2.52

21.71 ± 1.94

23.03 ± 1.64

T-BIL

0.014 ± 0.008

0.022 ± 0.018

0.020 ± 0.018

0.019 ± 0.014

IP

6.50 ± 1.17

6.19 ± 0.99

5.43 ± 0.73*

5.32 ± 0.60*

TG

48.30 ± 24.07

55.22 ± 30.67

45.80 ± 19.99

50.30 ± 24.38

CPK

375.20 ± 290.40

1004.67 ± 2174.69

231.50 ± 124.83

245.70 ± 106.73

Na

140.10 ± 1.45

140.22 ± 0.67

141.40 ± 5.21

141.00 ± 1.05

K

4.02 ± 1.15

3.62 ± 0.73

3.40 ± 0.17

3.37 ± 0.26

Cl

102.20 ± 0.79

102.44 ± 1.13

103.60 ± 3.13

103.20 ± 1.69

  1. Note. ALB(g/dL), Albumin; ALP(IU/L), Alkaline phosphatase; CA(mg/dL), Calcium; CHO(mg/dL), Total cholesterol; CRE(mg/dL), Creatinine; GGT(IU/L), Gamma glutamyl transpeptidase; GLU(mg/dL), Glucose; AST(IU/L), Aspartate aminotransferase; ALT(IU/L), Alanine aminotransferase; LDH(IU/L), Lactate dehydrogenase; MG(mg/dL), Magnesium; TP(g/dL), Total protein; UA(mg/dL), Uric acid; BUN(mg/dL), Blood urea nitrogen; T-BIL(mg/dL), Total bilirubin; IP(mg/dL), Inorganic phosphorus; TG(mg/dL), Triglyceride; CPK(U/L), Creatine phosphokinase; Na(mmol/L), Sodium; K(mmol/L), Potassium; Cl(mmol/L), Chloride.
  2. *Significant difference vs. control, p < 0.05
  3. **Significant difference vs. control, p < 0.01
Back to article page

Particle and Fibre Toxicology

ISSN: 1743-8977

Contact us