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Table 4 Serum values for female rats after 90-day oral administration of silver nanoparticles (mean ± S.D.)

From: Subchronic oral toxicity of silver nanoparticles

  Dose (mg/Kg)
  0 (n = 10) 30 (n = 9) 125 (n = 10) 500 (n = 10)
ALB 2.78 ± 0.08 2.73 ± 0.10 2.75 ± 0.24 2.63 ± 0.09
ALP 237.50 ± 29.05 241.22 ± 22.12 253.50 ± 25.42 314.80 ± 42.13**
CA 10.42 ± 0.60 10.11 ± 0.26 10.08 ± 0.30 9.98 ± 0.27
CHO 107.50 ± 7.35 115.11 ± 12.36 116.30 ± 6.95 126.70 ± 12.39**
CRE 0.85 ± 0.16 0.96 ± 0.15 0.91 ± 0.10 0.90 ± 0.13
GGT 0.80 ± 0.42 1.11 ± 0.78 0.90 ± 0.57 0.80 ± 0.63
GLU 148.70 ± 20.09 146.33 ± 14.53 151.20 ± 16.48 151.30 ± 20.19
AST 94.80 ± 11.98 84.22 ± 23.82 84.20 ± 6.89 94.80 ± 38.14
ALT 67.70 ± 6.00 59.78 ± 10.57 61.10 ± 5.15 70.90 ± 22.00
LDH 722.00 ± 480.71 705.33 ± 612.27 496.90 ± 303.14 516.90 ± 245.26
MG 2.44 ± 0.17 2.30 ± 0.24 2.17 ± 0.08** 2.18 ± 0.15**
TP 6.30 ± 0.17 6.14 ± 0.22 6.08 ± 0.14* 6.03 ± 0.23*
UA 1.12 ± 0.39 0.97 ± 0.31 0.86 ± 0.19 0.87 ± 0.12
BUN 23.61 ± 2.57 22.26 ± 2.52 21.71 ± 1.94 23.03 ± 1.64
T-BIL 0.014 ± 0.008 0.022 ± 0.018 0.020 ± 0.018 0.019 ± 0.014
IP 6.50 ± 1.17 6.19 ± 0.99 5.43 ± 0.73* 5.32 ± 0.60*
TG 48.30 ± 24.07 55.22 ± 30.67 45.80 ± 19.99 50.30 ± 24.38
CPK 375.20 ± 290.40 1004.67 ± 2174.69 231.50 ± 124.83 245.70 ± 106.73
Na 140.10 ± 1.45 140.22 ± 0.67 141.40 ± 5.21 141.00 ± 1.05
K 4.02 ± 1.15 3.62 ± 0.73 3.40 ± 0.17 3.37 ± 0.26
Cl 102.20 ± 0.79 102.44 ± 1.13 103.60 ± 3.13 103.20 ± 1.69
  1. Note. ALB(g/dL), Albumin; ALP(IU/L), Alkaline phosphatase; CA(mg/dL), Calcium; CHO(mg/dL), Total cholesterol; CRE(mg/dL), Creatinine; GGT(IU/L), Gamma glutamyl transpeptidase; GLU(mg/dL), Glucose; AST(IU/L), Aspartate aminotransferase; ALT(IU/L), Alanine aminotransferase; LDH(IU/L), Lactate dehydrogenase; MG(mg/dL), Magnesium; TP(g/dL), Total protein; UA(mg/dL), Uric acid; BUN(mg/dL), Blood urea nitrogen; T-BIL(mg/dL), Total bilirubin; IP(mg/dL), Inorganic phosphorus; TG(mg/dL), Triglyceride; CPK(U/L), Creatine phosphokinase; Na(mmol/L), Sodium; K(mmol/L), Potassium; Cl(mmol/L), Chloride.
  2. *Significant difference vs. control, p < 0.05
  3. **Significant difference vs. control, p < 0.01