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Table 8 Histopathological findings for male rats after 90-day oral administration of silver nanoparticles

From: Subchronic oral toxicity of silver nanoparticles

GROUP Control Low Middle High
Number of animals 10 10 10 10
  N % N % N % N %
Liver No microscopic findings 5/10 50 3/10 30 0/10 0 3/10 30
  Abnormality 5/10 50 7/10 70 10/10 100 7/10 70
     Hyperplasia bile duct minimum 4/10 40 7/10 70 8/10 80 6/10 60
    mild 0/10 0 0/10 0 1/10 10 0/10 0
     Vacuolation hepatocellular minimum 1/10 10 0/10 0 0/10 0 0/10 0
     Necrosis focal minimum 0/10 0 4/10 40 3/10 30 4/10 40
   lobular moderate 0/10 0 0/10 0 1/10 10 0/10 0
   multifocal moderate 0/10 0 0/10 0 1/10 10 0/10 0
     Hemorrhage    0/10 0 0/10 0 1/10 10 0/10 0
     Pigmentation    0/10 0 1/10 10 0/10 0 2/10 20
Kidneys No microscopic findings 10/10 100 10/10 100 9/10 90 6/10 60
  Abnormality 0/10 0 0/10 0 1/10 10 4/10 40
     Basophilia tubular minimum 0/10 0 0/10 0 1/10 10 2/10 20
     Inflammation focal minimum 0/10 0 0/10 0 0/10 0 1/10 10
   tubular minimum 0/10 0 0/10 0 0/10 0 1/10 10
Lungs No microscopic findings 9/10 90 10/10 100 9/10 90 7/10 70
  Abnormality 1/10 10 0/10 0 1/10 10 3/10 30
     Inflammation focal minimum 1/10 10 0/10 0 0/10 0 1/10 10
     Histocytosis    0/10 0 0/10 0 1/10 10 0/10 0
     Mineralization   minimum 0/10 0 0/10 0 0/10 0 2/10 20
     Anthracosis    0/10 0 0/10 0 0/10 0 1/10 10
Intestines No microscopic findings 10/10 100 10/10 100 2/10 20 2/10 20
  Abnormality 0/10 0 0/10 0 8/10 80 8/10 80
     Pigment villi yellow 0/10 0 0/10 0 1/10 10 8/10 80
    faint yellow 0/10 0 0/10 0 7/10 70 0/10 0
Heart No microscopic findings 10/10 100 10/10 100 8/10 80 8/10 80
  Abnormality 0/10 0 0/10 0 2/10 20 2/10 20
     Inflammation left ventricle minimum 0/10 0 0/10 0 2/10 20 1/10 10
   right ventricle minimum 0/10 0 0/10 0 0/10 0 1/10 10
Eyes No microscopic findings 10/10 100 10/10 100 10/10 100 9/10 90
  Abnormality 0/10 0 0/10 0 0/10 0 1/10 10
     Inflammation Harderian gland minimum 0/10 0 0/10 0 0/10 0 1/10 10
Pancreas No microscopic findings 10/10 100 10/10 100 10/10 100 8/10 80
  Abnormality 0/10 0 0/10 0 0/10 0 2/10 20
     Inflammation pancreas minimum 0/10 0 0/10 0 0/10 0 2/10 20