|
GROUP
|
Control
|
Low
|
Middle
|
High
|
|---|
|
Number of animals
|
10
|
10
|
10
|
10
|
| | | | |
N
|
%
|
N
|
%
|
N
|
%
|
N
|
%
|
|
Liver
|
No microscopic findings
|
5/10
|
50
|
2/10
|
20
|
2/10
|
20
|
3/10
|
30
|
| |
Abnormality
|
5/10
|
50
|
8/10
|
80
|
8/10
|
80
|
7/10
|
70
|
| |
Hyperplasia
|
bile duct
|
minimum
|
3/10
|
30
|
7/10
|
70
|
8/10
|
80
|
7/10
|
70
|
| |
Necrosis
|
focal
|
minimum
|
0/10
|
0
|
2/10
|
20
|
2/10
|
20
|
1/10
|
10
|
| | |
central vein
| |
0/10
|
0
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
| |
Fibrosis
| |
minimum
|
2/10
|
20
|
1/10
|
10
|
2/10
|
20
|
1/10
|
10
|
| |
Pigmentation
| | |
0/10
|
0
|
0/10
|
0
|
4/10
|
40
|
1/10
|
10
|
|
Kidneys
|
No microscopic findings
|
5/10
|
50
|
2/10
|
20
|
3/10
|
30
|
1/10
|
10
|
| |
Abnormality
|
5/10
|
50
|
8/10
|
80
|
7/10
|
70
|
9/10
|
90
|
| |
Mineralization
|
unilateral
|
minimum
|
4/10
|
40
|
7/10
|
70
|
5/10
|
50
|
5/10
|
50
|
| | | |
mild
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
0/10
|
0
|
| | |
bilateral
|
minimum
|
1/10
|
10
|
1/10
|
10
|
1/10
|
10
|
4/10
|
40
|
|
Lungs
|
No microscopic findings
|
10/10
|
100
|
10/10
|
100
|
9/10
|
90
|
10/10
|
100
|
| |
Abnormality
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
0/10
|
0
|
| |
Histocytosis
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
0/10
|
0
|
|
Intestines
|
No microscopic findings
|
10/10
|
100
|
10/10
|
100
|
10/10
|
100
|
5/10
|
50
|
| |
Abnormality
|
0/10
|
0
|
0/10
|
0
|
0/10
|
0
|
5/10
|
50
|
| |
Pigment
|
villi
|
yellow
|
0/10
|
0
|
0/10
|
0
|
0/10
|
0
|
0/10
|
0
|
| | | |
faint yellow
|
0/10
|
0
|
0/10
|
0
|
0/10
|
0
|
5/10
|
50
|
|
Eyes
|
No microscopic findings
|
8/10
|
80
|
9/10
|
90
|
9/10
|
90
|
9/10
|
90
|
| |
Abnormality
|
2/10
|
20
|
1/10
|
10
|
1/10
|
10
|
1/10
|
10
|
| |
Inflammation
|
Harderian gland
|
minimum
|
2/10
|
20
|
1/10
|
10
|
1/10
|
10
|
1/10
|
0
|
|
Pancreas
|
No microscopic findings
|
10/10
|
100
|
10/10
|
100
|
10/10
|
100
|
9/10
|
90
|
| |
Abnormality
|
0/10
|
0
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
| |
Inflammation
|
pancreas
|
minimum
|
0/10
|
0
|
0/10
|
0
|
0/10
|
0
|
1/10
|
10
|
