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Table 9 Histopathological findings for female rats after 90-day oral administration of silver nanoparticles

From: Subchronic oral toxicity of silver nanoparticles

GROUP Control Low Middle High
Number of animals 10 10 10 10
     N % N % N % N %
Liver No microscopic findings 5/10 50 2/10 20 2/10 20 3/10 30
  Abnormality 5/10 50 8/10 80 8/10 80 7/10 70
     Hyperplasia bile duct minimum 3/10 30 7/10 70 8/10 80 7/10 70
     Necrosis focal minimum 0/10 0 2/10 20 2/10 20 1/10 10
   central vein   0/10 0 0/10 0 0/10 0 1/10 10
     Fibrosis   minimum 2/10 20 1/10 10 2/10 20 1/10 10
     Pigmentation    0/10 0 0/10 0 4/10 40 1/10 10
Kidneys No microscopic findings 5/10 50 2/10 20 3/10 30 1/10 10
  Abnormality 5/10 50 8/10 80 7/10 70 9/10 90
     Mineralization unilateral minimum 4/10 40 7/10 70 5/10 50 5/10 50
    mild 0/10 0 0/10 0 1/10 10 0/10 0
   bilateral minimum 1/10 10 1/10 10 1/10 10 4/10 40
Lungs No microscopic findings 10/10 100 10/10 100 9/10 90 10/10 100
  Abnormality 0/10 0 0/10 0 1/10 10 0/10 0
     Histocytosis 0/10 0 0/10 0 1/10 10 0/10 0
Intestines    No microscopic findings 10/10 100 10/10 100 10/10 100 5/10 50
     Abnormality 0/10 0 0/10 0 0/10 0 5/10 50
     Pigment villi yellow 0/10 0 0/10 0 0/10 0 0/10 0
    faint yellow 0/10 0 0/10 0 0/10 0 5/10 50
Eyes No microscopic findings 8/10 80 9/10 90 9/10 90 9/10 90
  Abnormality 2/10 20 1/10 10 1/10 10 1/10 10
     Inflammation Harderian gland minimum 2/10 20 1/10 10 1/10 10 1/10 0
Pancreas No microscopic findings 10/10 100 10/10 100 10/10 100 9/10 90
  Abnormality 0/10 0 0/10 0 0/10 0 1/10 10
     Inflammation pancreas minimum 0/10 0 0/10 0 0/10 0 1/10 10