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Table 9 Histopathological findings for female rats after 90-day oral administration of silver nanoparticles

From: Subchronic oral toxicity of silver nanoparticles

GROUP

Control

Low

Middle

High

Number of animals

10

10

10

10

    

N

%

N

%

N

%

N

%

Liver

No microscopic findings

5/10

50

2/10

20

2/10

20

3/10

30

 

Abnormality

5/10

50

8/10

80

8/10

80

7/10

70

 

   Hyperplasia

bile duct

minimum

3/10

30

7/10

70

8/10

80

7/10

70

 

   Necrosis

focal

minimum

0/10

0

2/10

20

2/10

20

1/10

10

  

central vein

 

0/10

0

0/10

0

0/10

0

1/10

10

 

   Fibrosis

 

minimum

2/10

20

1/10

10

2/10

20

1/10

10

 

   Pigmentation

  

0/10

0

0/10

0

4/10

40

1/10

10

Kidneys

No microscopic findings

5/10

50

2/10

20

3/10

30

1/10

10

 

Abnormality

5/10

50

8/10

80

7/10

70

9/10

90

 

   Mineralization

unilateral

minimum

4/10

40

7/10

70

5/10

50

5/10

50

   

mild

0/10

0

0/10

0

1/10

10

0/10

0

  

bilateral

minimum

1/10

10

1/10

10

1/10

10

4/10

40

Lungs

No microscopic findings

10/10

100

10/10

100

9/10

90

10/10

100

 

Abnormality

0/10

0

0/10

0

1/10

10

0/10

0

 

   Histocytosis

0/10

0

0/10

0

1/10

10

0/10

0

Intestines

   No microscopic findings

10/10

100

10/10

100

10/10

100

5/10

50

 

   Abnormality

0/10

0

0/10

0

0/10

0

5/10

50

 

   Pigment

villi

yellow

0/10

0

0/10

0

0/10

0

0/10

0

   

faint yellow

0/10

0

0/10

0

0/10

0

5/10

50

Eyes

No microscopic findings

8/10

80

9/10

90

9/10

90

9/10

90

 

Abnormality

2/10

20

1/10

10

1/10

10

1/10

10

 

   Inflammation

Harderian gland

minimum

2/10

20

1/10

10

1/10

10

1/10

0

Pancreas

No microscopic findings

10/10

100

10/10

100

10/10

100

9/10

90

 

Abnormality

0/10

0

0/10

0

0/10

0

1/10

10

 

   Inflammation

pancreas

minimum

0/10

0

0/10

0

0/10

0

1/10

10