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Figure 1 | Particle and Fibre Toxicology

Figure 1

From: Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells

Figure 1

Interaction of Libby six-mix with LP9/TERT-1 cells and resultant changes in cell viability. SEM images of (A) Libby six-mix, (B) crocidolite asbestos, (C) LP9/TERT-1 cells alone, and (D) LP9/TERT-1 cells interacting with 75×106 μm2/cm2 Libby six-mix. White arrows indicate cell membrane blebbing and exudate formation. All magnifications X 1500, scale bars = 10 μm. (E) Viability of LP9/TERT-1 cells following 24 h of exposure to glass beads (non-pathogenic control) or Libby six-mix as determined using 0.4% trypan blue staining of cells detached with Accutase. Bars denote the mean ± SEM of 3 individual experiments where n = 3 replicates per group per experiment. * p < 0.05 compared to glass beads.

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