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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells

Figure 4

Gene expression of oxidative stress markers, HO-1 in LP9/TERT-1 cells and HO-1 and SOD2 in HKNM-2 cells. HO-1 expression in (A) LP9/TERT-1 cells following exposure to 15 or 75×106 μm2/cm2 Libby six-mix or glass beads (GB) for 24 h. * p < 0.05 in comparison to all other groups. (B) HO-1 expression in HKNM-2 cells following exposure to 15 or 75×106 μm2/cm2 Libby six-mix or crocidolite asbestos for 24 h. * p < 0.05 in comparison to all other particle-exposed groups. (C) SOD2 expression in HKNM-2 cells following exposure to 15 or 75×106 μm2/cm2 crocidolite asbestos or Libby six-mix for 24 h. * p < 0.05 in comparison to lower concentration of respective fiber. † p < 0.05 in comparison to respective concentrations of crocidolite asbestos. Bars denote the mean ± SEM of n = 2 or 3 samples per group per experiment.

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