Table 2 Top 10 gene expression alterations by Libby six-mix (15×106 μm2/cm2) in LP9/TERT-1 and HKNM-2 mesothelial cells
Gene Name (Abbreviation) | Fold Changea | LP9/TERT-1 qRT-PCR Validation | HKNM-2 qRT-PCR Resultsb | |
|---|---|---|---|---|
Increased: | 8 h | 24 h | Â | Â |
Tissue factor pathway inhibitor-2 (TFPI2) | NC | 11* | -- | -- |
Interleukin 8 C-terminal variant, 211506_s_t (IL8) | NC | 9* | -- | 3 |
Prostaglandin-endoperoxide synthase 2 (PTGS2) | NC | 7* | -- | -- |
Interleukin 8 (IL8) | NC | 7* | 14* | -- |
Pyruvate dehydrogenase kinase, isozyme 4 (PDK4) | NC | 7* | -- | -- |
Pleckstrin homology-like domain, family A, member 1 (PHLDA1) | NC | 5* | -- | -- |
Chemokine (C-X-C motif) ligand 3 (CXCL3) | NC | 5 | -- | -- |
Activating transcription factor 3 (ATF3) | NC | 5* | 5* | 5 |
Superoxide dismutase 2, mitochondrial (SOD2) | 4* | 5* | -- | 2 |
Annexin 14 (ANX14) | NC | 4 | -- | -- |
| Â | Â | Â | Â | -- |
Decreased: | Â | Â | Â | -- |
Oxytocin receptor (OXTR) | NC | 5* | -- | -- |
Chromosome 5 open reading frame 13 (C5orf13) | NC | 4* | -- | -- |
Chromosome 21 open reading frame 7 (C21orf7) | NC | 3* | -- | -- |
Cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1) | NC | 3* | -- | -- |
Calponin 1, basic, smooth muscle (CNN1) | NC | 3 | -- | -- |
Cyclin-dependent kinase inhibitor 1C (CDKN1C) | NC | 3 | -- | -- |
Methyltransferase like 7A (METTL7A) | NC | 2* | -- | -- |
Periplakin (PPL) | NC | 2* | -- | -- |
Kelch-like 4 (KLHL4) | NC | 2 | -- | -- |
Phospholipase C-like 1 (PLCL1) | NC | 2* | -- | -- |