Figure 4
Response of pulmonary inflammation markers in the bronchoalveolar lavage fluid (BALF). Concentrations of Interleukin-6 (IL-6) (3a), osteopontin (3b), and macrophage inflammatory protein-2 (MIP-2) in lung homogenate (3c) following intratracheal (i.t.) instillation of sham and Augsburg particulate matter (PM2.5-AB, exposed) in SHRs are shown. Bars represent arithmetic mean values ± SE of sham (n = 6) and exposure groups (n = 6). IL-6 exhibited a typical dose-time response in the BALF. Osteopontin in the BALF and MIP-2 in the lung homogenate (3c) was affected only at the highest dose (1000 μg). *: Significantly (p < 0.05) higher than sham and 250 μg exposed at 24 h **: Significantly (p < 0.05) higher than sham and exposed at day 1. †: Significantly (p < 0.05) higher than 500 μg exposed at day 1 and 3