Particle and Fibre Toxicology

Table 2 Experimental design of cardio physiological, pulmonary and systemic response..

From: Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs)

Instillation
	Adaptatiion		Baseline	Post exposure
Cardiovascular response	Day -2	Day-1	Day 0	Night 1	Night 2	Night 3	Night 4	Night 5
	Acclimatization		√	√	√	√	√	√
Telemetry (n = 5)*	No change		BP	BP	BP	BP	BP	BP
			HR	HR	HR	HR	HR	HR
*ambient particle-mediated pulmonary and systemic response*
Pulmonary resposne	Day 1 (24 h; Group A)					Day 3 (72 h; Group B)
Dose/rat	250 μg	500 μg		1000 μg		500 μg	1000 μg
BALF (n = 6)	√	√		√		√	√
Lung tissue (n = 6)	√	√		√		√	√
Pulmonary histopathology (n = 2)	√	√		√		√	√
Systemic response
Blood (n = 8)	√	√		√		√	√
Cardiac tissue (n = 6)	√	√		√		√	√
Cardiac histopathology (n = 2)	√	√		√		√	√

*Number of exposed animals is given. A similar number of animals were intratrachealy instilled with pyrogene-free distilled water and served as controls or sham. Blood : blood collected from retro arbitral sinus and abdominal aorta.. BP and HR: blood pressure and heart rate were the two primary parameters measured for the cardiovascular response.

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ISSN: 1743-8977

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