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Table 2 NP based drug delivery systems: a list of NP conjugated platforms for delivery across the BBB

From: Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging

NP Platform Drug (and effects) References
PBCA NP coated with Polysorbate 80 dalargin (analgesic) [133, 134, 137]
PBCA NP coated with Polysorbate 80 doxorubicin (DOX) (anti-tumour antibiotic) [139, 146, 147]
PBCA NP coated with Polysorbate 80 kytorphin (analgesic) [141]
PBCA NP NMDA receptor antagonist MRZ 2/576 (antagonist) [140]
PBCA NP coated with Polysorbate 80 tubocurarine (Increased BBB permeability) [142]
PEG-PHDCA PrPres Specific Drug in Prion Disease [143]
PBCA NP coated with Polysorbate 80 tacrine (Anti Alzheimer's Drug) [144]
PBCA NP coated with Polysorbate 80 rivastigmine (Anti Alzheimer's Drug) [145]
PBCA NP coated with Polysorbate 80 gemcitabine (anti glioma drug) [148]
DMAEMA/HEMA (pH sensitive) paclitaxel [75]
LDC-polysorbate 80 NPs diminazene (anti human African trypanosomiasis (HAT)) [153]
DO-FUdR-SLN 5-fluoro-2'-deoxyuridine (FUdR) (Very efficient in brain targeting) [154]
PBCA NPs, MMA-SPM NPs, and SLNs stavudine (D4T), delavirdine (DLV), and saquinavir (SQV) (anti HIV agents and enhanced BBB permeability) [155]
PBCA NPs coated with apolipoprotein B and E loperamide and dalargin (increased BBB permeability) [77]