Table 2 NP based drug delivery systems: a list of NP conjugated platforms for delivery across the BBB
NP Platform | Drug (and effects) | References |
|---|---|---|
PBCA NP coated with Polysorbate 80 | dalargin (analgesic) | |
PBCA NP coated with Polysorbate 80 | doxorubicin (DOX) (anti-tumour antibiotic) | |
PBCA NP coated with Polysorbate 80 | kytorphin (analgesic) | [141] |
PBCA NP | NMDA receptor antagonist MRZ 2/576 (antagonist) | [140] |
PBCA NP coated with Polysorbate 80 | tubocurarine (Increased BBB permeability) | [142] |
PEG-PHDCA | PrPres Specific Drug in Prion Disease | [143] |
PBCA NP coated with Polysorbate 80 | tacrine (Anti Alzheimer's Drug) | [144] |
PBCA NP coated with Polysorbate 80 | rivastigmine (Anti Alzheimer's Drug) | [145] |
PBCA NP coated with Polysorbate 80 | gemcitabine (anti glioma drug) | [148] |
DMAEMA/HEMA (pH sensitive) | paclitaxel | [75] |
LDC-polysorbate 80 NPs | diminazene (anti human African trypanosomiasis (HAT)) | [153] |
DO-FUdR-SLN | 5-fluoro-2'-deoxyuridine (FUdR) (Very efficient in brain targeting) | [154] |
PBCA NPs, MMA-SPM NPs, and SLNs | stavudine (D4T), delavirdine (DLV), and saquinavir (SQV) (anti HIV agents and enhanced BBB permeability) | [155] |
PBCA NPs coated with apolipoprotein B and E | loperamide and dalargin (increased BBB permeability) | [77] |