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Figure 9 | Particle and Fibre Toxicology

Figure 9

From: Acute exposure of mice to high-dose ultrafine carbon black decreases susceptibility to pneumococcal pneumonia

Figure 9

Bronchoalveolar lavage (BAL) fluid cytokines. BAL was done at the 24 hr post final exposure. Uninfected mice received; i) 2× doses of PBS alone, ii) 2× 500 μg ultrafine-carbon black (UF-CB) alone. Infected mice received either 2× doses of PBS, or 2× 500 μg ultrafine-carbon black (UF-CB), followed by instillation of pneumococci. Infection increased BAL fluid keratinocyte-derived chemokine/growth-related oncogene (KC/GRO), Tumor necrosis factor (TNF)-α, and interferon (IF)-γ (P < 0.05, PBS alone vs. PBS+infection). UF-CB pre-treatment resulted in lower levels of murine IL-8 and IF-γ. Bar represents mean, n = 5. * P < 0.05 by unpaired t test.

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