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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Pulmonary exposure to carbon black nanoparticles and vascular effects

Figure 4

Progression of atherosclerotic plaques in a) aorta or b) brachiocephalic arteries (BCA) from 48-49 weeks old apoE-/- mice exposed to carbon black by i.t. instillation. In a) plaque area is expressed as % of intimal surface of aorta covered in plaques (left). The means are represented by horizontal lines (n = 11); each symbol represent the result from one animal. On the right, images are shown of the intimal surface of the aorta from the ascending aorta to the femoral arteries representative of the mean plaque areas in the control group (upper) and the exposed group (lower). The atherosclerotic plaques are discernible as white areas on the light grey background of normal aorta. In b) plaque area is expressed as % of lumen of BCA occupied by plaques (left). The means are represented by horizontal lines (n = 7); each symbol represent the result from one animal. On the right, images are shown of BCA sections representative of the means in the control group (left) and the exposed group (right).

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