Table 3 Overview significant changes and trends after gold instillation
From: Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation
| Â | Local pulmonary effects | Systemic effects | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | Inflammatory cells | Cytokines | Cell damage | Acute phase proteins | ||||
|  | Cells | Macrophages | Neutrophils | IL-6 | TNF-α | ALP | Fibrinogen | CRP |
50 nm single | - | - | ↑ | - | - | - | - | ↑* |
250 nm single | - | - | ↑* | ↑ | ↑ | - | ↑* | ↑* |
50 nm agg | - | - | ↑ | - | ↑ | ↑* | ↑* | ↑* |
250 nm agg | ↑ | ↑ | - | - | - | - | - | ↑* |
quartz | ↑↑* | - | ↑↑* | - | - | ↑↑* | - | ↑* |