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Table 3 Overview significant changes and trends after gold instillation

From: Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation

  Local pulmonary effects Systemic effects
  Inflammatory cells Cytokines Cell damage Acute phase proteins
  Cells Macrophages Neutrophils IL-6 TNF-α ALP Fibrinogen CRP
50 nm single - - - - - - ↑*
250 nm single - - ↑* - ↑* ↑*
50 nm agg - - - ↑* ↑* ↑*
250 nm agg - - - - - ↑*
quartz ↑↑* - ↑↑* - - ↑↑* - ↑*
  1. * indicates a statistically significant effect (P < 0.05).