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Figure 2 | Particle and Fibre Toxicology

Figure 2

From: Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: Implication of chemical components and NF-κB signaling

Figure 2

UFP1 and UFP2 induced oxidative stress in HAEC. (A) UFP1 and UFP2 similarly stimulated intracellular superoxide production. HAEC were treated with 50 μg/ml (15.6 μg/cm2) of UFP1 or UFP2 for 1 hour in the presence of NBT. Superoxide production was measured as absorbance at 700 nm. (B) Both UFP1 and UFP2 stimulated the expression of oxidative stress response genes. HAEC were treated for 4 hours with 50 ug/ml of UFP1 or UFP2. The expression of stress response gene HO-1, OKL38 and TF mRNA was measured by qRT- PCR. (C = control; * versus control, n = 3, P < 0.01; ** versus control, n = 3, P < 0.05; # UFP2 versus UFP1, n = 3, P < 0.01; ## UFP2 versus UFP1, n = 3, P < 0.05)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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